تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial
Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial
 
لغة الوثيقة : الانجليزية 
المستخلص : A randomized double-blind clinical trial was performed to test the safety and efficacy of a low-molecular-weight heparin, tinzaparin (Innohep), for the management of acute painful vasoocclusive crisis characteristic of sickle cell anemia (SCA). We studied 253 patients with acute painful crisis but with no other complications of SCA, randomized to treatment or control groups. In the treatment group, 127 patients received tinzaparin at 175 IU/kg, subcutaneous once daily, along with supportive care including morphine analgesia; in the control group, 126 patients received placebo and the same supportive care. The maximal experimental treatment period was seven days. Analysis revealed a statistically significant reduction in number of days with the severest pain score, overall duration of painful crisis, and duration of hospitalization (p < 0.05 for each comparison of tinzaparin vs. placebo). The decline in pain intensity was sharper for tinzaparin-treated patients, and complications consisted of two minor bleeding events that were reported and treated by cessation of tinzaparin. This investigation demonstrated that tinzaparin, administered at its approved treatment regimen, reduced the severity and duration of acute crisis of SCA 
ردمد : 0340-6245 
اسم الدورية : Thrombosis and Haemostasis 
المجلد : 98 
العدد : 2 
سنة النشر : 1428 هـ
2007 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Sunday, August 30, 2009 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
سعاد الجاعونيAl-Jaouni, Soad باحث مشاركدكتوراه 
محمد قاريQari, Mohammed باحث رئيسيدكتوراه 
محمد العرضاويArdawi, Mohammed باحث مشاركدكتوراه 
فاتن السايسAl-Sayes, Fatin باحث مشاركدكتوراه 

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اسم الملفالنوعالوصف
 29009.zip zip 

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