Document Details Document Type : Article In Journal  Document Title : Microfluidic Spinning of Cell-Responsive Grooved Microfibers Microfluidic Spinning of Cell-Responsive Grooved Microfibers   Subject : physics  Document Language : English  Abstract : Engineering living tissues that simulate their natural counterparts is a dynamic area of research. Among the various models of biological tissues being developed, fiber-shaped cellular architectures, which can be used as artificial blood vessels or muscle fibers, have drawn particular attention. However, the fabrication of continuous microfiber substrates for culturing cells is still limited to a restricted number of polymers (e.g., alginate) having easy processability but poor cell-material interaction properties. Moreover, the typical smooth surface of a synthetic fiber does not replicate the micro-and nanofeatures observed in vivo, which guide and regulate cell behavior. In this study, a method to fabricate photocrosslinkable cell-responsive methacrylamide-modified gelatin (GeIMA) fibers with exquisite microstructured surfaces by using a microfluidic device is developed. These hydrogel fibers with microgrooved surfaces efficiently promote cell encapsulation and adhesion. GeIMA fibers significantly promote the viability of cells encapsulated in/or grown on the fibers compared with similar grooved alginate fibers used as controls. Importantly, the grooves engraved on the GeIMA fibers induce cell alignment. Furthermore, the GeIMA fibers exhibit excellent processability and could be wound into various shapes. These microstructured GeIMA fibers have great potential as templates for the creation of fiber-shaped tissues or tissue microstructures  ISSN : 1616-301X  Journal Name : ADVANCED FUNCTIONAL MATERIALS  Volume : 25  Issue Number : 15  Publishing Year : 1435 AH 2015 AD  Article Type : Article  Added Date : Monday, August 21, 2017  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email X Shin, Shi, X Investigator Doctorate   S Ostrovidov Ostrovidov, S Researcher Doctorate   Y.H Zhao Zhao, Y.H Researcher     X.B Liang, Liang, X.B Researcher Doctorate   M Kasuya Kasuya, M Researcher Doctorate   K Kurihara Kurihara, K Researcher Doctorate   K Nakajima Nakajima, K Researcher Doctorate   H Bae Bae, H Researcher Doctorate   H.K Wu Wu, H.K Researcher Doctorate chhkwu@ust.hk A Khademhosseini Khademhosseini, A Researcher Doctorate alik@rics.bwh.harvard.edu Files File Name Type Description  42713.pdf pdf   Back To Researches Page