Document Details

Document Type : Article In Journal 
Document Title :
An Efficient Approach to the Synthesis of Highly Congested 9,10-Dihydrophenanthrene-2,4-dicarbonitriles and Their Biological Evaluation as Antimicrobial Agents
An Efficient Approach to the Synthesis of Highly Congested 9,10-Dihydrophenanthrene-2,4-dicarbonitriles and Their Biological Evaluation as Antimicrobial Agents
 
Document Language : English 
Abstract : An efficient and novel method for the synthesis in moderate to good yield (72%-84%) of a series of 3-amino-1-substituted-9,10-dihydrophenanthrene-2,4-dicarbonitriles 1-5 via one-pot multi-component reactions of aldehydes, malononitrile, 1-tetralone and ammonium acetate has been delineated. Cyclocondensation attempts of aminocyanophenanthrene derivatives 1, 2, 4 and 5 with acetic anhydride in the presence of conc. H2SO4 failed and instead the diacetylamino derivatives 10-13 were obtained. All prepared compounds were structurally elucidated by various spectroscopic methods and X-ray crystallography. N,N-diacetylamino-derivatives of phenanthrene have shown good antimicrobial activity. 
ISSN : 1420-3049 
Journal Name : MOLECULES 
Volume : 18 
Issue Number : 12 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Sunday, July 16, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
H FaidallahFaidallah, H Researcher  
K Al-ShaikhAl-Shaikh, k Researcher  
T SobahiSobahi, T Researcher  
K KhanKhan, K Researcher  
A AsiriAsiri, A Researcher  

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