Document Details
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Document Type |
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Thesis |
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Document Title |
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THEEFFECT OF LIGHT CURABLERESIN MODIFIED GLASS IONOMER VARNISH ON INHIBITING THE PROGRESSION OF NON-CAVITATED PROXIMAL CARIOUS LESIONS: A RANDOMIZED CONTROLLED TRIAL تأثيرورنيش الأيونومر الزجاجي المعدل بالراتينج المتصلب بالضوءعلىمنع تفاقم نخرالأسنانالغيرمجوف على السطوح الجانبية: تجربة منضبطة عشوائية |
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Subject |
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Faculty of Dentistry |
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Document Language |
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Arabic |
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Abstract |
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Background: The light curable resin modified glass ionomer (RMGI) varnish is a site-specific protective varnish for dentin and enamel tooth surfaces. It is believed to slowly release fluoride for up to six months. However, studies examining its application on noncavitated proximal carious lesions are lacking.
Aims: To assess and compare the effect of the light curable RMGI varnish (Vanish XT varnish) with preventive standard of care measures to preventive standard of care measures alone (application of 5% sodium fluoride varnish, dietary counseling, and oral hygiene instructions) on inhibiting the progression or promoting the regression of noncavitated proximal carious lesions in primary molars and permanent first molars after six and 12 months of treatment by radiographic, near-infrared light transillumination using the DIAGNOcam, and clinical examination. Also, to compare between these three diagnostic methods in: monitoring progression, arrest, and regression of the proximal carious lesions; and in the children´s perception of the pain from each of these methods.
Materials and Methods: The study was a split mouth randomized controlled clinical trial in 60 healthy 5-8-year-old children with 92 pairs of noncavitated proximal carious lesions in 80 primary molars and 12 in permanent first molars. They were screened using bitewing radiographs to have at least one pair of matched bilateral proximal carious lesions in enamel or outer dentin third. The lesions were also assessed by the DIAGNOcam and clinically after temporary tooth separation. Cavitated lesions were excluded. The children’s perception of pain was evaluated after each of the diagnostic procedures. The lesions were randomly assigned either to the experimental group, which received the Vanish XT varnish with preventive standard of care measures or to the control group, which received preventive standard of care measures only. After six and 12 months, the regression, progression, or arrest of the lesions were assessed by the three diagnostic methods used at baseline. The teeth received the same baseline treatment according to their group allocation.
Results: At the six-months follow-up, significantly more lesions regressed in the experimental group radiographically (18.6%), by DIAGNOcam (15.1%), and clinically (10.5%) than the control group (8.1%, 4.7%, and 2.3% respectively) (P=0.044, 0.021, and 0.029 respectively). More control group lesions progressed radiographically and by DIAGNOcam (20.9% in both) than in experimental group (15.1% and 16.3% respectively), but it was not significant (P= 0.321 and 0.433 respectively). At the 12-months follow-up, significantly more lesion regressed clinically in the experimental group (14.8%) than the control groups (2.5%) (P=0.009), more lesions also regressed in the experimental group radiographically and by DIAGNOcam (28.4%, and 14.8% respectively) than the control group (17.3% and 7.4% respectively) but was not significant (P=0.092 and 0.134 respectively). While, more control group lesions progressed radiographically, by DIAGNOcam, and clinically (30.9%, 35.8 % and 34.6% respectively) than in experimental group (22.2%, 29.6%, and 24.7% respectively), but was not significant (P= 0.213 and 0.402 and 0.169 respectively). There was a significant positive correlation in monitoring the progression, arrest, and regression of the proximal carious lesions between the clinical and bitewing radiographs (r=0.127, P=0.021), clinical and DIAGNOcam (r=0.165, P=0.003), and bitewing radiographs and DIAGNOcam methods (r=0.111, P=0.043), but the correlations were weak. The DIAGNOcam method provoked a significantly higher level of pain (mean ± SD= 3.69 ± 3.10, P<0.001) than the temporary tooth separation for the clinical examination (mean ±SD= 2.31 ± 2.51) and the bitewing radiographs (mean ± SD= 1.75 ± 2.11).
Conclusion: These results showed that the Vanish XT varnish with preventive standard of care measures was significantly superior to preventive standard of care measures alone in promoting the regression of noncavitated proximal carious lesions by radiographic, DIAGNOcam, and clinical assessment after six months of treatment and significantly promoting the clinical regression after 12-months of treatment. The Vanish XT varnish has shown a promising potential as an adjunct to preventive standard of care measures in promoting the regression and inhibiting the progression of noncavitated proximal carious lesions. Further longitudinal studies with larger samples and longer follow-ups are recommended to reach evidence-based recommendations. |
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Supervisor |
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Prof. Dr. Najlaa M. H. Alamoudi |
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Thesis Type |
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Doctorate Thesis |
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Publishing Year |
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1442 AH
2020 AD |
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Co-Supervisor |
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Dr. Eman A. M. El Ashiry |
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Added Date |
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Friday, January 29, 2021 |
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Researchers
| جيهان عبدالأحد خان | Khan, Jihan Abdulahad | Researcher | Master | |
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